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— Written By Sarah Lewis, PharmDUpdated on September 15, 2021 What is a coronary calcium scan? A coronary calcium scan is a type of CT (computed tomography) scan. CT scans are diagnostic medical imaging exams. They are not invasive and use X-rays and a computer to make cross-sectional images of the body. A coronary calcium scan makes pictures of the coronary arteries—the arteries that supply blood to the heart muscle. The images can show the amount of calcified plaque buildup inside the coronary arteries; plaque buildup is a sign of atherosclerosis. Other names for the test include CT coronary calcium scan, coronary calcium heart scan, calcium scan of the heart, and calcium scan test. Doctors generate a coronary artery calcium score from the scan. Why is a coronary calcium scan performed? A coronary calcium scan can help your doctor determine your risk of atherosclerotic heart disease, heart attack, and stroke. The test looks for calcium in the walls of the coronary arteries. The presence of calcium is a good indication of plaque buildup—the cause of atherosclerosis and coronary artery disease (CAD). Plaque is a waxy substance containing cholesterol and other substances. Calcium in plaque hardens it. Plaque buildup and CAD make serious health events, such as heart attack and stroke, more likely.A coronary calcium scan isn’t for everyone. Your doctor may only recommend a coronary calcium scan if your heart health risk is uncertain.Current guidelines, without the scan, use a formula to classify your risk of future heart disease. Your. CTisus 15,314 followers 11mo Our CT of the Coronary Arteries App is now available for iPhone 🫀 Download now for free ‎CTisus CT Coronary Arteries Our CT of the Coronary Arteries App is now available for iPhone 🫀 Download now for free CTisus on LinkedIn: ‎CTisus CT Coronary Arteries Agree Join LinkedIn Our CT of the Coronary Arteries App is now available for iPhone 🫀 Download now for free CTisus on LinkedIn: CTisus CT Coronary Arteries Agree Join LinkedIn Our CT of the Coronary Arteries App is quickly becoming our most popular app of the year Download now for free: CTisus on LinkedIn: CTisus CT Coronary Arteries Skip to ‎Read reviews, compare customer ratings, see screenshots and learn more about CTisus CT Coronary Arteries. Download CTisus CT Coronary Arteries and enjoy it on your iPhone, iPad The HeartFlow® analysis is the first and only non-invasive test used to diagnose coronary artery disease (CAD). This cardiac test produces a personalized 3D model with exceptional visualization of the coronary arteries and enables physicians to develop effective treatment plans, unique to each patient. Historically, this detailed information was only available through an invasive heart procedure. The information gathered from the test, including how a blockage impacts the flow of blood to the heart, can help your doctor develop your customized treatment.What is Coronary Artery Disease?Coronary artery disease (CAD) is the leading cause of death of men and women in the United States. CAD can develop when arteries that lead to the heart narrow or become blocked – reducing blood flow to the heart. When this occurs, chest pain, heart attacks and death can result.Who is a candidate for a HeartFlow Analysis?If your doctor needs more information after a CT scan of the heart, he or she may order a HeartFlow Analysis. This test can be performed in the same clinic visit as your CT scan. There is not additional risk from the test.What to expect during a HeartFlow Analysis?HeartFlow technology will use the CT scan results to create a personalized digital 3D model of your coronary arteries. The analysis will calculate how much your blockages limit your blood flow in the heart.Your cardiologist will receive the digital, color-coded 3D model of your arteries and will use it to develop a customized treatment plan for you.Benefits of HeartFlow Analysis:Provides a

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— Written By Sarah Lewis, PharmDUpdated on September 15, 2021 What is a coronary calcium scan? A coronary calcium scan is a type of CT (computed tomography) scan. CT scans are diagnostic medical imaging exams. They are not invasive and use X-rays and a computer to make cross-sectional images of the body. A coronary calcium scan makes pictures of the coronary arteries—the arteries that supply blood to the heart muscle. The images can show the amount of calcified plaque buildup inside the coronary arteries; plaque buildup is a sign of atherosclerosis. Other names for the test include CT coronary calcium scan, coronary calcium heart scan, calcium scan of the heart, and calcium scan test. Doctors generate a coronary artery calcium score from the scan. Why is a coronary calcium scan performed? A coronary calcium scan can help your doctor determine your risk of atherosclerotic heart disease, heart attack, and stroke. The test looks for calcium in the walls of the coronary arteries. The presence of calcium is a good indication of plaque buildup—the cause of atherosclerosis and coronary artery disease (CAD). Plaque is a waxy substance containing cholesterol and other substances. Calcium in plaque hardens it. Plaque buildup and CAD make serious health events, such as heart attack and stroke, more likely.A coronary calcium scan isn’t for everyone. Your doctor may only recommend a coronary calcium scan if your heart health risk is uncertain.Current guidelines, without the scan, use a formula to classify your risk of future heart disease. Your

2025-04-24
User9484

The HeartFlow® analysis is the first and only non-invasive test used to diagnose coronary artery disease (CAD). This cardiac test produces a personalized 3D model with exceptional visualization of the coronary arteries and enables physicians to develop effective treatment plans, unique to each patient. Historically, this detailed information was only available through an invasive heart procedure. The information gathered from the test, including how a blockage impacts the flow of blood to the heart, can help your doctor develop your customized treatment.What is Coronary Artery Disease?Coronary artery disease (CAD) is the leading cause of death of men and women in the United States. CAD can develop when arteries that lead to the heart narrow or become blocked – reducing blood flow to the heart. When this occurs, chest pain, heart attacks and death can result.Who is a candidate for a HeartFlow Analysis?If your doctor needs more information after a CT scan of the heart, he or she may order a HeartFlow Analysis. This test can be performed in the same clinic visit as your CT scan. There is not additional risk from the test.What to expect during a HeartFlow Analysis?HeartFlow technology will use the CT scan results to create a personalized digital 3D model of your coronary arteries. The analysis will calculate how much your blockages limit your blood flow in the heart.Your cardiologist will receive the digital, color-coded 3D model of your arteries and will use it to develop a customized treatment plan for you.Benefits of HeartFlow Analysis:Provides a

2025-03-26
User8808

2022;359:1–6.Crossref | PubMedBeijk MA, Vlastra WV, Delewi R, et al. Myocardial infarction with non-obstructive coronary arteries: a focus on vasospastic angina. Neth Heart J 2019;27:237–45.Crossref | PubMedMontone RA, Niccoli G, Russo M, et al. Clinical, angiographic and echocardiographic correlates of epicardial and microvascular spasm in patients with myocardial ischaemia and non-obstructive coronary arteries. Clin Res Cardiol 2020;109:435–43.Crossref | PubMedWaters DD, Chaitman BR, Dupras G, et al. Coronary artery spasm during exercise in patients with variant angina. Circulation 1979;59:580–5.Crossref | PubMedSchmitz K, Groth N, Mullvain R, et al. Prevalence, clinical factors, and outcomes associated with myocardial infarction with nonobstructive coronary artery. Crit Pathw Cardiol 2021;20:108–13.Crossref | PubMedPasupathy S, Lindahl B, Litwin P, et al. Survival in patients with suspected myocardial infarction with nonobstructive coronary arteries: a comprehensive systematic review and meta-analysis from the MINOCA global collaboration. Circ Cardiovasc Qual Outcomes 2021;14:e007880.Crossref | PubMedMileva N, Nagumo S, Mizukami T, et al. Prevalence of coronary microvascular disease and coronary vasospasm in patients with nonobstructive coronary artery disease: systematic review and meta-analysis. J Am Heart Assoc 2022;11:e023207.Crossref | PubMedAdachi Y, Ikeda N, Sakakura K, et al. Intractable coronary spastic angina improvement after continuous combined estrogen-progestin hormonal contraception use in a premenopausal woman. Intern Med 2016;55:2639–42.Crossref | PubMedHuang J, Kumar S, Toleva O, Mehta PK. Mechanisms of coronary ischemia in women. Curr Cardiol Rep 2022;24:1273–85.Crossref | PubMedCamilli M, Russo M, Rinaldi R, et al. Air pollution and coronary vasomotor disorders in patients with myocardial ischemia and unobstructed coronary arteries. J Am Coll Cardiol 2022;80:1818–28.Crossref | PubMedTalarico GP, Crosta ML, Giannico MB, et al. Cocaine and coronary artery diseases: a systematic review of the literature. J Cardiovasc Med (Hagerstown) 2017;18:291–4.Crossref | PubMedDesai A, Mohammed T, Patel KN, et al. 5-fluorouracil rechallenge after cardiotoxicity. Am J Case Rep 2020;21:e924446.Crossref | PubMedMontone RA, Gurgoglione FL, Del Buono MG, et al. Interplay between myocardial bridging and coronary spasm in patients with myocardial ischemia and non-obstructive coronary arteries: pathogenic and prognostic implications. J Am Heart Assoc 2021;10:e020535.Crossref | PubMedAkbas T, Kaya A, Altun G, et al. Cases of allergic coronary syndrome (Kounis syndrome): what we should know. Nagoya J Med Sci 2022;84:664–72.Crossref | PubMedWong CW, Luis S, Zeng I, Stewart RA. Eosinophilia and coronary artery vasospasm. Heart Lung Circ 2008;17:488–96.Crossref | PubMedForman MB, Oates JA, Robertson D, et al. Increased adventitial mast cells in a patient with coronary spasm. N Engl J Med 1985;313:1138–41.Crossref | PubMedTakagi Y, Takahashi J, Yasuda S, et al. Prognostic stratification of patients with vasospastic angina: a comprehensive clinical risk score developed by the Japanese Coronary Spasm Association. J Am Coll Cardiol 2013;62:1144–53.Crossref | PubMedKaski JC, Tousoulis D, Gavrielides S, et al. Comparison of epicardial coronary artery tone and reactivity in Prinzmetal’s variant angina and chronic

2025-04-12
User4169

A worried patient who had often been told “nothing was wrong in your heart,” and prevent the blind empirical use of antianginals with side-effects such as hypotension or bradycardia.In summary, invasive testing for coronary vasospasm is part of a comprehensive assessment of INOCA and MINOCA, with the aims of achieving symptom relief and improving the quality of life and prognosis in these patients. Clinical PerspectiveCoronary vasospasm can be evaluated only through invasive studies with reliable accuracy.The most commonly used provocation agent in the invasive coronary artery spasm assessment is acetylcholine.Multiple protocols for acetylcholine use are available; practical and commonly used protocols are discussed in this paper.Unified protocols and results interpretation are paramount to accurate diagnosis and a standardized approach to treatment in vasospastic angina. References Prinzmetal M, Kennamer R, Merliss R, et al. Angina pectoris. I. A variant form of angina pectoris; preliminary report. Am J Med 1959;27:375–88.Crossref | PubMedNakamura M, Takeshita A, Nose Y. Clinical characteristics associated with myocardial infarction, arrhythmias, and sudden death in patients with vasospastic angina. Circulation 1987;75:1110–6.Crossref | PubMedOliva PB, Potts DE, Pluss RG. Coronary arterial spasm in prinzmetal angina. Documentation by coronary arteriography. N Engl J Med 1973;288:745–51.Crossref | PubMedFord TJ, Rocchiccioli P, Good R, et al. Systemic microvascular dysfunction in microvascular and vasospastic angina. Eur Heart J 2018;39:4086–97.Crossref | PubMedCenko E, Bergami M, Varotti E, Bugiardini R. Vasospastic angina and its relationship with the coronary microcirculation. Curr Pharm Des 2018;24:2906–10.Crossref | PubMedOng P, Athanasiadis A, Borgulya G, et al. High prevalence of a pathological response to acetylcholine testing in patients with stable angina pectoris and unobstructed coronary arteries. The ACOVA Study (Abnormal COronary VAsomotion in patients with stable angina and unobstructed coronary arteries). J Am Coll Cardiol 2012;59:655–62.Crossref | PubMedNakayama N, Kaikita K, Fukunaga T, et al. Clinical features and prognosis of patients with coronary spasm-induced non-ST-segment elevation acute coronary syndrome. J Am Heart Assoc 2014;3:e000795.Crossref | PubMedMontone RA, Niccoli G, Fracassi F, et al. Patients with acute myocardial infarction and non-obstructive coronary arteries: safety and prognostic relevance of invasive coronary provocative tests. Eur Heart J 2018;39:91–8.Crossref | PubMedMontone RA, Rinaldi R, Del Buono MG, et al. Safety and prognostic relevance of acetylcholine testing in patients with stable myocardial ischaemia or myocardial infarction and non-obstructive coronary arteries. EuroIntervention 2022;18:e666–76.Crossref | PubMedPirozzolo G, Seitz A, Athanasiadis A, et al. Microvascular spasm in non-ST-segment elevation myocardial infarction without culprit lesion (MINOCA). Clin Res Cardiol 2020;109:246–54.Crossref | PubMedFord TJ, Stanley B, Good R, et al. Stratified medical therapy using invasive coronary function testing in angina: the CorMicA trial. J Am Coll Cardiol 2018;72:2841–55.Crossref | PubMedSeitz A, Martinez Pereyra V, Sechtem U, Ong P. Update on coronary artery spasm 2022 - a narrative review. Int J Cardiol

2025-04-20
User5361

Bases, methodological considerations and clinical implications. Atherosclerosis 2021;318:14–21.Crossref | PubMedFeenstra RGT, Seitz A, Boerhout CKM, et al. Principles and pitfalls in coronary vasomotor function testing. EuroIntervention 2022;17:1271–80.Crossref | PubMedKunadian V, Chieffo A, Camici PG, et al. An EAPCI expert consensus document on ischaemia with non-obstructive coronary arteries in collaboration with European Society of Cardiology working group on coronary pathophysiology and microcirculation endorsed by coronary vasomotor disorders international study group. Eur Heart J 2020;41:3504–20.Crossref | PubMedFord TJ, Ong P, Sechtem U, et al. Assessment of vascular dysfunction in patients without obstructive coronary artery disease: why, how, and when. JACC Cardiovasc Interv 2020;13:1847–64.Crossref | PubMedTakahashi T, Samuels BA, Li W, et al. Safety of provocative testing with intracoronary acetylcholine and implications for standard protocols. J Am Coll Cardiol 2022;79:2367–78.Crossref | PubMedSueda S, Kohno H, Ochi T, et al. Overview of the pharmacological spasm provocation test: comparisons between acetylcholine and ergonovine. J Cardiol 2017;69:57–65.Crossref | PubMedGulati M, Levy PD, Mukherjee D, et al. AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR guideline for the evaluation and diagnosis of chest pain: executive summary: a report of the American College of Cardiology/American Heart Association joint committee on clinical practice guidelines. Circulation 2021;144:e368–454.Crossref | PubMedMarrone A, Pavasini R, Scollo E, et al. Acetylcholine use in modern cardiac catheterization laboratories: a systematic review. J Clin Med 2022;11:1129.Crossref | PubMedOng P, Athanasiadis A, Borgulya G, et al. Clinical usefulness, angiographic characteristics, and safety evaluation of intracoronary acetylcholine provocation testing among 921 consecutive white patients with unobstructed coronary arteries. Circulation 2014;129:1723–30.Crossref | PubMedSueda S, Miyoshi T, Sasaki Y, et al. Gender differences in sensitivity of acetylcholine and ergonovine to coronary spasm provocation test. Heart Vessels 2016;31:322–9.Crossref | PubMedAziz A, Hansen HS, Sechtem U, et al. Sex-related differences in vasomotor function in patients with angina and unobstructed coronary arteries. J Am Coll Cardiol 2017;70:2349–58.Crossref | PubMedPargaonkar VS, Lee JH, Chow EKH, et al. Dose-response relationship between intracoronary acetylcholine and minimal lumen diameter in coronary endothelial function testing of women and men with angina and no obstructive coronary artery disease. Circ Cardiovasc Interv 2020;13:e008587.Crossref | PubMedSato K, Kaikita K, Nakayama N, et al. Coronary vasomotor response to intracoronary acetylcholine injection, clinical features, and long-term prognosis in 873 consecutive patients with coronary spasm: analysis of a single-center study over 20 years. J Am Heart Assoc 2013;2:e000227.Crossref | PubMedJansen TPJ, Elias-Smale SE, van den Oord S, et al. Sex differences in coronary function test results in patient with angina and nonobstructive disease. Front Cardiovasc Med 2021;8:750071.Crossref | PubMedKim YG, Kim HJ, Choi WS, et al. Does a negative ergonovine provocation test truly predict freedom from variant angina? Korean Circ J 2013;43:199–203.Crossref | PubMedKashima K, Tachibana H, Nakamura K, et al. Long-term outcome of patients with ergonovine induced coronary constriction not

2025-04-09
User4809

Stable angina pectoris. J Am Coll Cardiol 1991;17:1058–62.Crossref | PubMedMiyata K, Shimokawa H, Yamawaki T, et al. Endothelial vasodilator function is preserved at the spastic/inflammatory coronary lesions in pigs. Circulation 1999;100:1432–7.Crossref | PubMedLudmer PL, Selwyn AP, Shook TL, et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 1986;315:1046–51.Crossref | PubMedSurma M, Wei L, Shi J. Rho kinase as a therapeutic target in cardiovascular disease. Future Cardiol 2011;7:657–71.Crossref | PubMedShimokawa H. Cellular and molecular mechanisms of coronary artery spasm: lessons from animal models. Jpn Circ J 2000;64:1–12.Crossref | PubMedNohria A, Grunert ME, Rikitake Y, et al. Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease. Circ Res 2006;99:1426–32.Crossref | PubMedHung MJ, Cherng WJ, Cheng CW, Li LF. Comparison of serum levels of inflammatory markers in patients with coronary vasospasm without significant fixed coronary artery disease versus patients with stable angina pectoris and acute coronary syndromes with significant fixed coronary artery disease. Am J Cardiol 2006;97:1429–34.Crossref | PubMedSpecchia G, de Servi S, Falcone C, et al. Coronary arterial spasm as a cause of exercise-induced ST-segment elevation in patients with variant angina. Circulation 1979;59:948–54.Crossref | PubMedYasue H, Horio Y, Nakamura N, et al. Induction of coronary artery spasm by acetylcholine in patients with variant angina: possible role of the parasympathetic nervous system in the pathogenesis of coronary artery spasm. Circulation 1986;74:955–63.Crossref | PubMedGlueck CJ, Valdes A, Bowe D, et al. The endothelial nitric oxide synthase T-786c mutation, a treatable etiology of Prinzmetal’s angina. Transl Res 2013;162:64–6.Crossref | PubMedSatake K, Lee JD, Shimizu H, et al. Relation between severity of magnesium deficiency and frequency of anginal attacks in men with variant angina. J Am Coll Cardiol 1996;28:897–902.Crossref | PubMedHubert A, Seitz A, Pereyra VM, et al. Coronary artery spasm: the interplay between endothelial dysfunction and vascular smooth muscle cell hyperreactivity. Eur Cardiol 2020;15:e12.Crossref | PubMedToyo-oka T, Aizawa T, Suzuki N, et al. Increased plasma level of endothelin-1 and coronary spasm induction in patients with vasospastic angina pectoris. Circulation 1991;83:476–83.Crossref | PubMedLerman A, Holmes DR, Jr, Bell MR, et al. Endothelin in coronary endothelial dysfunction and early atherosclerosis in humans. Circulation 1995;92:2426–31.Crossref | PubMedKugiyama K, Ohgushi M, Motoyama T, et al. Nitric oxide-mediated flow-dependent dilation is impaired in coronary arteries in patients with coronary spastic angina. J Am Coll Cardiol 1997;30:920–6.Crossref | PubMedPries AR, Badimon L, Bugiardini R, et al. Coronary vascular regulation, remodelling, and collateralization: mechanisms and clinical implications on behalf of the working group on coronary pathophysiology and microcirculation. Eur Heart J 2015;36:3134–46.Crossref | PubMedLanza GA, Careri G, Crea F. Mechanisms of coronary artery spasm. Circulation 2011;124:1774–82.Crossref | PubMedRadico F, Cicchitti V, Zimarino M, De Caterina R. Angina pectoris and myocardial ischemia in

2025-04-23

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